Poster (download) Angelika Timofeeva1, Oksana Vasilchenko2, Mariya Pirogova3, Ivan Fedorov4, Vitaliy Chagovets5, Larisa Ezhova6, Roman Shmakov7, Gennadiy Sukhikh81FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, avtimofeeva28@gmail.com2FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, vasilchenko-on@mail.ru3FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, pirogovamariya@gmail.com4FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, i_fedorov@oparina4.ru5FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, vvchagovets@gmail.com6FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, l_ezhova@oparina4.ru7FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, r_shmakov@oparina4.ru8FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, g_sukhikh@oparina4.ru It is well-known that abnormal placental invasion is a condition characterized by pathological invasion of chorionic villi into the the basal layer of the uterus that is complicated by massive obstetric hemorrhage, blood transfusions, a need for hysterectomy and even mortality. The altered miRNA expression profiles were found by deep sequencing not only directly in the area of pathological invasion, but also in the outside distant placenta areas with more pronounced changes in the former case. An increase in the level of miR-21-5p, miR-25-3p, miR-92a-3p, miR-320a in maternal plasma may indicate abnormally invasiveВ placenta and potentially be used in the early diagnosis and management of this condition.