MICRORNAS (221, 429) ARE CORRELATION WITH LYMPHOCYTES OF AXILLARY LYMPH NODES IN EXPERIMENTAL BREAST CANCER

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Aleksey Kabakov¹, Alexandr Lykov², Oleg Kazakov³, Alexandr Poveshchenko⁴, Olga Poveshchenko⁵, Dmitriy Strunkin⁶, Lyudmila Gulyaeva⁷, Andrey Letyagin⁸, Vladimir Konenkov^9
1RICEL-Branch of IC&G SB RAS, kabakov_av@mail.ru
²RICEL-Branch of IC&G SB RAS, aplykov2@mail.ru
³RICEL-Branch of IC&G SB RAS, kazakoff_oleg@mail.ru
⁴RICEL-Branch of IC&G SB RAS, poveshchenkoa200@mail.ru
⁵RICEL-Branch of IC&G SB RAS, poveschenkoov@yandex.ru
⁶RIMBB FRC FTM, strunkind@mail.ru
⁷RIMBB FRC FTM, gulyaeva@soramn.ru
⁸RICEL-Branch of IC&G SB RAS, letyaginay@bionet.nsc.ru
⁹RICEL-Branch of IC&G SB RAS, vikonenkov@gmail.com

The study of concentration miRNA (21, 221, 222, and 429) in serum, lymph of the thoracic duct and breast cancer tissue, as well as the cellular composition of axillary lymph node in Wistar female rats in chemically induced breast cancer. Concentration microRNA (-221, -429) in the tissues breast cancer and lymph are correlated with a decrease in number of lymphocytes in medullary cords of axillary lymph nodes.