Placental transcriptome co-expression analysis reveals key biomarkers and pathways of preeclampsia

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Trifonova E.¹, Zarubin A.², Babovskaya A.³, Markov A.⁴, Stepanov V.⁵
¹TNRMC RAS, Tomsk, Russia; SibMed, Tomsk, Russia, ekaterina.trifonova@medgenetics.ru
²TNRMC RAS, Tomsk, Russia, aleksei.zarubin@medgenetics.ru
³TNRMC RAS, Tomsk, Russia, anastasia.babovskaya@medgenetics.ru
⁴TNRMC RAS, Tomsk, Russia, anton.markov@medgenetics.ru
⁵TNRMC RAS, Tomsk, Russia, vadim.stepanov@medgenetics.ru

Preeclampsia is a complication of pregnancy characterized by new-onset hypertension and proteinuria of gestation, with serious consequences for mother and infant. Although a vast amount of research has been performed on the pathogenesis of preeclampsia, the underlying mechanisms of this multisystemic disease have remained to be fully elucidated. We identified the significant role of disturbance of intercellular interactions and regulation of proteins modification in placental tissue during the development of the PE. Among the genes involved in these key pathways, 9 hub genes and 3 master regulators were identified from the co-expression and upstream analysis networks. The present study may provide a basis for exploring potential novel genes and pathways as therapeutic targets for preeclampsia.

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Elena Ignatieva

3 years ago

Can you explain the result from Fig.4 in more details? Were there 86 genes associated only with PE from 6 clusters (from Fig.1)? And what type of interactions did you analyzed (Fig.4)? I see edges of different colors.

Was the result presented on Fig.3 obtained after analysis of the network presented in Fig.4 or basing on the other data?