The development of compensatory processes in the liver and kidney in conditions of distant tumor growth

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Nataliya Bgatova¹, Asel Rakhmetova², Saule Bakhbaeva³, Viktoriia Makarova⁴, Iuliia Taskaeva^5
1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences,Novosibirsk, Russia, n_bgatova@ngs.ru
²Pavlodar State University; Pavladar, Kazakhsta, asel-rakhmetova@mail.ru
³Pavlodar State University; Pavladar, Kazakhstan, saule0577@mail.ru
⁴Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences Novosibirsk, Russia, shedina_vika@mail.ru
⁵Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences Novosibirsk, Russia, inabrite@yandex.ru

Development of malignant tumor accompanied endogenous intoxication of an organism having a mixed nature, in particular due to dysfunction of organs detoxification and excretion damaging effect of tumor metabolism. The active process of moving toxic and biologically active substances formed during tumor progression from the primary focus by blood and lymph flow leads to damage of distant organ. The aim of this work was to identify structural changes in the liver and kidney under the conditions of modeling distant tumor growth. For modelingВ  tumor growth, hepatocarcinoma-29 (G-29) cells were used. G-29 cells were injected into the muscle of the right thigh of CBA mice [1]. The material for research was collected after 3, 7, 13, and 30 days of the experiment. The structure of the liver and kidney was studied by the method of light and electron microscopy. Both destructive and compensatory changes in the liver and kidney were revealed in conditions of distant tumor growth. In the liver, a decrease a size of hepatocytes and concentration of organelles, as well as development of autophagy, as a mechanism for maintaining intracellular homeostasis, were noted. In the kidney at the early stages of the development of the tumor growth, structural signs of filtration barrier disorde were shown. Subsequent development of compensatory hypertrophy of podocytes and glomerular capillary endothelium, as well as autophagy in the epithelium of the proximal nephron were noted.