Influence of the Factors of Maternal Milieu on Taste Preferences and Metabolic Parameters in Mouse Male and Female Offspring

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Denisova Elena¹, Makarova Elena², Savinkova M^3
1Laboratory of Physiological Genetics Institute of Cytology and Genetics SB RAS Novosibirsk, RussiaLaboratory of Physiological Genetics Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, elena_nsib@list.ru
²Laboratory of Physiological Genetics Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, enmakarova@gmail.com
³Department of Physiology Novosibirsk State University Novosibirsk, Russia, m.savinkova@g.nsu.ru

 

Waiting is currently the leader among noncommunicable diseases. Calorie overload causes the development of obesity. It was shown that the prenatal and early postnatal state affects the susceptibility to obesity and can affect taste preferences [1], however, the mechanisms mediating the maternal effect on taste preferences in the offspring are unknown. The adipose tissue leptin hormone may be one of the factors mediating the maternal effect on the phenotype of the offspring. It has been shown that increasing the level of mites in the blood of pregnant women [2, 3] and programming the effects of leptins can be different in the offspring of different sexes. It is not known whether this is due to the positive programmatic effect of maternal leptin with a predisposition to its influence on taste preferences. These studies were supposed to affect pregnancy, muscle metabolism, the frequency of burns caused by diet and taste preferences in offspring of different sexes.