Predicting elongation efficiency of gene translation for annotation of bacterial genomes: a case study for biosynthetic gene clusters of nonribosomal peptides

Poster (download)

414

A.I. Klimenko¹, Yu.G. Matushkin², D.A. Afonnikov^3
1Kurchatov Genomics Center, Institute of Cytology and Genetics, klimenko@bionet.nsc.ru
²ICG SB RAS, mat@bionet.nsc.ru
³ICG SB RAS, NSU, ada@bonet.nsc.ru

The gene expression levels for bacteria are largely determined by the efficiency of translation elongation. We have performed bioinformatic elongation efficiency analysis of NRP biosynthetic gene clusters (BGCs) obtained from ANTISMASH-DB using whole-genome sequences of bacterial genomes that are available at NCBI Genbank. The analysis has provided the information about distribution of nonribosomal peptide biosynthetic gene clusters in bacteria and their putative translation elongation efficiency.