• June 29, 2020
  • N/A

Genetic aspects of internet-dependence in teenagers

Poster (download) Marina Smolnikova1, Sergey Tereshchenko21Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, smarinv@yandex.ru2Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, legise@mail.ru The rapid emergence and spread of Internet addiction in adolescent populations, combined with a rapid change in consumed content due to mobile access availability and the new access devices, are new challenges for classical psychology and fundamental medicine that require urgent solutions. The presence of the genetic component of Internet addiction was convincingly shown in different populations, but to date the specific genes involved in the mechanisms of such heritability have not been well identified. The aim of the study was to investigate the role of candidate neurotransmitters and to perform a population analysis of candidate genes polymorphisms for the Internet addiction formation. As a result of the analysis, 7 Internet-dependent adolescents and 39 adolescents with a tendency to Internet-dependent behavior were identified. The frequencies of genotype distribution in the population sampling of Caucasians (n = 302) В were obtained: * CC 59.6%, * CT 40.4%, * TT 0% (rs1800497 DRD2); * AA 23.8%, AG 52.4%, * GG 23.8% (rs4680 COMT); * CC 37.4%, * CG 46.0%, * GG 16.6% (rs2229910 NTRK3). The results will help to open new perspectives in assessing the fundamental neurobiological causes for the Internet addiction and the personalization of therapeutic approaches in Internet dependent adolescents.

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Genetic association of the rs4680 COMT and rs1044396 CHRNA4 with internet addiction in Siberian adolescents

Marina Smolnikova1, Sergey Tereshchenko21Laboratory of cell-molecular physiology and pathology Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS Krasnoyarsk, Russia, smarinv@yandex.ru2Clinical department somatic and mental health of children Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS Krasnoyarsk, Russia, legise@mail.ru Abstract As the use of the Internet grows, the issue of the pathological and problematic Internet use (PIU) as well as online games has been relevant. Research related to a family history of temperament and mental disorders has rapidly been developing. Having the genetic component of developing Internet addiction was shown by twin studies using various populations, however, to date, the specific genes involved in the mechanisms of such heritability are not exactly identified. Materials: Genotyping of rs4680 COMT and rs1044396 CHRNA4 in 345 adolescents with different severity of internet addiction (tested with Chen Internet Addiction Scale) were analyzed. Results: The predominant allelic variant rs4680*G COMT in Khakass teenagers regardless of the severity of Internet addiction compared with Russian teenagers have been shown. It is important that some significant differences have also been observed between Russian PIU (45.5%) and Khakas PIU (63.8%) (OR 0.47, p = 0.024). We revealed that rs1044396 CC genotype prevalence progressively increase with IA severity: AIU group (n=179) – 19.0%, MIU group (n=82) – 32.9%, and PIU group (n=84) – 34.5%. The CC variant of rs1044396 CHRNA4 showed significantly higher anxiety scores as compared with carriers of T-allele. Our results correspond to similar results in the adult in another populations and are pilot in Russia; they are important for understanding the pathogenesis of IA at an early stage of addiction formation.

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