Poster (download) Video (download) Kakurina G.V.1, Kolegova E.S2, Staheeva M.N.3, Cheremisina O.V.4, Kondakova I.V.5, Choynzonov E.L.61Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, kakurinagv@oncology.tomsk.ru2Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, biochem@oncology.tomsk.ru3Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, stakheyevam@oncology.tomsk.ru4Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, onco@tnimc.ru5Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, biochem@oncology.tomsk.ru6Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, onco@tnimc.ru To determine the markers of metastasis, it is important to study the molecular characteristics of tumor progression among patients with Squamous cell carcinoma of the larynx and larynxopharynx (L/L SCC). The aim of the study was to study the relationship between the level of actin binding proteins (ABS) (adenylyl cyclase-associated protein 1 (CAP1), cofilin 1, ezrin, fascin 1 and profilin 1) in the blood serum of patients with L/L SCC with the main clinical and morphological characteristics and to assess the possibility of their use as markers of metastasis. Several serum ABPs (CAP1, profilin1 and fascin 1) have been identified as potential markers of metastasis of L/L SCC. For the presented sample of patients a metastasis prognosis model was obtained. For further conclusions about the clinical value of the proposed metastasis markers, further studies with an expanding sample of patients are needed.

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