Topology of the associative cytokine gene network in primary open-angle glaucoma

by Prokofiev V. | Shevchenko A. | Konenkov V. | Trunov A. | Research Institute of Clinical and
Experimental Lymрhology – Branch of the Institute of Cytology and Ge-netics SB RAS, Novosibirsk,
Russia of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of Clinical and
Experimental Lymрhology – Branch of the Institute of Cytology and Ge-netics SB RAS, Novosibirsk,
Russia of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of Clinical and
Experimental Lymрhology – Branch of the Institute of Cytology and Ge-netics SB RAS, Novosibirsk,
Russia of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Novosibirsk Branch of The academician
S.N. Fyodorov Federal State Institution «Intersectoral Research and Technology Complex Eye
Microsurgery», Ministry of Health of the Russian Federation, Novosibirsk, Russia

Primary open-angle glaucoma (POAG) is one of the leading causes of global irreversible
blindness. Therefore, it remains a serious medical and social problem throughout the world.
There is an assumption that the predisposition to the development of glaucoma is due to
polymorphism of the regulatory regions of coding genes that determine the individual level
of production of cytokines, chemokines, and growth factors. The aim of our study was to
conduct a comprehensive bioinformatics analysis of polymorphic regions of the cytokine
network genes to identify the relationship between the features of the topology of this
network with the development of POAG.Type here a short description of your report.

Poster 1_Prokofiev V_Abstracts1_BGRS-2022