Effect of estrogen and progesterone on the frequency and spectrum of karyotypically abnormal cells in cultured uterine leiomyomas

by Alla S. Koltsova | Olga A. Efimova | Vladislav S. Baranov | Maria I. Yarmolinskaya | Nikolai I. Polenov |
Anna A. Pendina | D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology 

Uterine leiomyomas (ULs) are the most common tumors of female reproductive tract. In spite of their benign nature, ULs can rapidly grow to a large size and seriously affect women’s health. UL symptoms include pelvic pain, excessive bleeding, infertility and recurrent pregnancy loss. ULs are clonal sex steroid hormone-dependent tumors. Up to 50% of ULs have chromosomal abnormalities, which are considered to occur secondary during UL tumorigenesis. We recently demonstrated that cytogenetically different UL cell clones have an unequal ability to grow in vivo and in vitro. In the present study, we aimed to check whether combined and isolated estrogen and progesterone treatment has an effect on both clonal spectrum and clonal proportion in ULs with an abnormal karyotype in vitro.

Poster_Koltsova AS_BGRSSB2022