by Miroshnichenko S.M. | Michurina S.V. | Rachkovskaya L.N. | Serykh A.E. | Ishchenko I.Yu. |
Rachkovsky E.E. | Letyagin A.Yu. | Zavyalov E.L. | FTR FTM Research Institute of biochemistry, NIIKEL |
Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and
Genetics, SB RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental Lymphology –
Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of
Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, SB RAS,
Novosibirsk, RussiaResearch Institute of Experimental and Clinical Medicine – Federal Research Center
for Fundamental and Translational Medicine, Novosibirsk, Russia | Research Institute of Clinical and
Experimental Lymphology – Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk,
Russia | Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology
and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental Lymphology
– Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of
Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, SB RAS,
Novosibirsk, Russia
Prolonged stress can cause a decrease in immunity, excessive accumulation of metabolites
and lead to pathological processes with the development of infectious, cardiovascular,
neurodegenerative diseases and cancer. Round-the-clock lighting, being a factor in the
violation of natural daily biorhythms, has a stressful effect on the body and causes an
imbalance in the secretion of melatonin. Violation of melatonin synthesis affects the
neuroendocrine system and immune reactivity, increasing stress pressure. Unbalanced
response and/or long-term exposure alters biochemical parameters, composition and
amount of metabolites and contributes to their accumulation. Sorbents can become one of
the factors for correcting the effects of stress. The use of a sorbent-based aluminum oxide
and polydimethylsiloxane alleviates the pressure of roundthe-clock lighting stress,
maintaining the viability of thymus cells, increasing the proliferation of young CD3low
lymphocytes and normalizing the cell cycle of thymus stromal cells. The sorbent had no
effect on the maturation and differentiation of T lymphocytes.