by Evgeny Ermakov | Mark Melamud | Daria Parshukova | Alexey Sizikov | Svetlana Ivanova | Georgy
Nevinsky | Valentina Buneva | Institute of Chemical Biology and Fundamental Medicine, SB RAS,
Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk,
Russia | Mental Health Research Institute, Tomsk National Research Medical Center, Tomsk, Russia |
Institute of Clinical Immunology, SB RAS, Novosibirsk, Russia | Mental Health Research Institute, Tomsk
National Research Medical Center, Tomsk, Russia | Institute of Chemical Biology and Fundamental
Medicine, SB RAS, Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB
RAS, Novosibirsk, Russia
Dysregulation of cytokine networks is known to be associated with various autoimmune
diseases including multiple sclerosis (MS) and systemic lupus erythematosus (SLE). Many
studies have shown changes in serum cytokine levels in MS and SLE. However, the detailed
changes in serum cytokine profiles in MS and SLE are poorly understood. Besides,
comparisons of cytokine profiles in these diseases have not been performed.
The aim of this work was to investigate changes in the serum cytokine profiles in MS and
SLE patients in comparison with healthy donors in one series of experiments.
The analysis was carried out in the following groups: a group of SLE patients – 60 people, a
group of MS patients – 55 people, a group of healthy donors – 36 people. The concentration
of 41 cytokines was determined using a MAGPIX multiplex analyzer.
Principal component analysis and discriminant least squares analysis showed that the
combined multicytokine profiles of the studied groups differed. It was shown that 13, 10 and
22 out of 41 cytokines were changed when comparing HS vs SLE, HS vs MS, and SLE vs
MS, respectively.
Thus, cytokine profiles in SLE and MS differ significantly both in comparison with healthy
individuals and between these diseases. These data will help to better understand the differences in cytokine network dysregulation in MS and SLE.
This work was supported by the Russian Science Foundation under grant number
20-15-00162.