by Nataliya Bgatova | Savchenko Sergey | Lamanov Alekcey | Letyagin Andrey | Miguel Antonio |
Research Institute of Clinical and Experimental Lymрhology –Branch of the Institute of Cytology and
Genetics Siberian Branch of Russian Academy of Sciences | Novosibirsk State Medical University |
Novosibirsk State Medical University | Research Institute of Clinical and Experimental Lymрhology
–Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences |
Novosibirsk State Medical University
The study of the heart revealed acute circulatory system disorders, dystrophic and
necrobiotic changes in cardiomyocytes. Foci of contractures of I-III degrees, myocytolysis of
cardiomyocytes were observed in the myocardium. Intracellular lipid inclusions were
detected in cardiomyocytes. In the zona glomerulosa of the adrenal cortex, dilated lumens of
blood capillaries, the presence of large lipid droplets in cortical adrenalocyte and necrosis of
individual cells were revealed. The medulla was characterized by medullary cells swelling
and destructive changes, significantly enlarged of blood capillaries lumens. In the zona
reticularis of the adrenal cortex, swelling of cortical adrenalocyte, accumulations of
erythrocytes, lymphocytes and plasma cells, and large lipid droplets in the lumen of
capillaries were observed. The most pronounced structural changes were noted in the zona
fasciculate of the adrenal cortex. The heterogeneity of cortical adrenalocyte of the content
of lipid inclusions was revealed. Cells with a small amount of lipid droplets, medium and
hypertrophied cells with a large amount of lipids in the cytoplasm were observed. Signs of
cell apoptosis were noted.
Conclusion: The data obtained indicate significant changes in the structure of the
myocardium and adrenal gland in patients with COVID-19. The revealed structural changes
can be informative in the development of cardioprotection to reduce mortality.
Acknowledgements: The study is supported by Research Institute of Clinical and
Experimental Lymphology – Branch of the Institute of Cytology and Genetics, SB RAS
(NFWNR-2022-0012).