by Alexander Pupyshev | Ph.D.
Three regimens of trehalose application rendered high therapeutic effect in the treatment of
acute pharmacomodel of Alzheimer’s disease caused by intraventricular injection of
fragment of amyloid-beta 25-35. Mice of C57Bl/6 recieved 2 or 4 % trehalose solution (plus
in intermittent mode) per os during 2 weeks as treatment. Activity of autophagy (LC3-II
marker), level of amyloid-beta, activity of neuroinflammation (Iba1 marker) in hypoccampus,
recovery of cognition (fear memory test) were studied. The highest effect was found for 4 %
trehalose and it was similar with impact on autophagy activity.