by Chadaeva Irina | Ponomarenko P. | Kozhemyakina R. | Suslov V. | Bogomolov A. | Klimova
N. | Shikhevich S. | Savinkova L. | Oshchepkov D. | Kolchanov N.A. | Markel
A. | Ponomarenko M. | ICG SB RAS
Here we sequenced hypothalamic transcriptomes of tame and aggressive rats,
identified their differentially expressed genes (DEGs), and applied principal
component analysis to compare them with all the known DEGs of domestic versus
wild animals that we could find. Two principal components, PC1 and PC2,
respectively explained 67% and 33% of DEGs variance between domestic and wild
animals.
On a laboratory model of the animal domestication, tame and aggressive rats, the
relationship of differential gene expression with two factors was shown – with
artificial selection (domestication) and intraspecific variability
Two processes were quantified, domestication and microevolution at the same scale
(genome-wide analysis)
They respectively explain 2/3 and 1/3 of the differences in differential gene
expression in domestic and wild animals as a response of genomes to the impact of
artificial and natural habitat factors