by Elizaveta Kulaeva | Academy of Biology and Biotechnology, Southern Federal University, Rostov-onDon, Russia
Long non-coding RNAs (lncRNAs) play a role in the pathogenesis
of acute myeloid leukemia (AML) by affecting gene expression, including in pediatric
AML. Deregulation of lncRNAs patterns has the potential to regulate tumor drug
resistance and sustaining of leukemic stem cells. Here we investigated the expression
patterns of lncRNAs and mRNAs in relapsed tumors compared to primary tumors, using
TARGET-AML project data