Natural selection against insufficiency in sarcomeric proteins reduces the risks of cardiomyopathy in humans versus the nearest wild congeners (chimpanzees)

by Karina Zolotareva | Irina Chadaeva | Bato Khandaev | Anton Bogomolov | Dmitry Oshchepkov | Maria Nazarenko | Mikhail Ponomarenko | Nikolay Kolchanov | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | […]

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Re-analysis of DNA methylation data from tuberculosisinfected individuals with a focus on target genes

by Babushkina Nadezhda | Bragina Elena | Gonchrova Irina | Markov Anton | Kucher Aksana | Nazarenko Maria | Research Institute of Medical Genetics, Tomsk National Research Medical Center RAS, Tomsk, Russia Along with the structural variability of the genome, epigenetic modifications can be significant for susceptibility to various, including infectious diseases. The aim of […]

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Re-analysis of DNA methylationin genes associated with bronchial asthma

by Babushkina Nadezhda | Bragina Elena | Gonchrova Irina | Markov Anton | Kucher Aksana | Babushkina Nadezhda | Nazarenko Maria | Research Institute of Medical Genetics, Tomsk National Research Medical Center RAS, Tomsk, Russia  To study the variability of gene methylation patterns, which in our previous studies showed associations with bronchial asthma and tuberculosis […]

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Exploring lncRNA-mRNA signatures in relapsed acute myeloid leukemia compared with primary tumors

by Elizaveta Kulaeva | Academy of Biology and Biotechnology, Southern Federal University, Rostov-onDon, Russia Long non-coding RNAs (lncRNAs) play a role in the pathogenesis of acute myeloid leukemia (AML) by affecting gene expression, including in pediatric AML. Deregulation of lncRNAs patterns has the potential to regulate tumor drug resistance and sustaining of leukemic stem cells. […]

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In silico determination of the risk haplotype for developing AMD

by Karpova N.S. | The Institute of General Pathology and Pathophysiology, Moscow, Russia Motivation and Aim: Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause of visual impairment in developed countries. Risk factors include environmental components and genetic determinants. 50% or more of the risk of developing AMD is due to mutations […]

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Effect of DNA-hydrolyzing catalytic IgGs from schizophrenia patients on cell viability of the SH-SY5Y cell line

by Epimakhova E.V. | Ermakov E.A. | Kazantseva D.V. | Smirnova L.P. | Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia | Institute of Chemical Biology and Fundamental Medicine, Laboratory of Repair Enzymes, Novosibirsk, Russia  Background: DNA-hydrolyzing catalytic IgGs have cytotoxic effects in autoimmune diseases [Sabirzyanova A.Z. et.al., […]

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The nearest and one-month effects of endovascular revascularization for patients with critical limb ischemia

by Sobolevskaya E.V., Smagin M.A., Hapaev R.S., Shumkov O.A., Nimaev V.V. | Laboratory of Operative Lymphology and Lymphatic Detoxification – Branch of the institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | V. Zelman Institute for Medicine and Psychology – Novosibirsk State University, Novosibirsk, Russia The method of endovascular revascularization has a number of […]

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